SS Richard Montgomery Matter
Warning: Drug and Grapefruit Food Interactions
Grapefruit is a citrus fruit rich in the
following nutrients: Vitamin C, Vitamin A, Vitamin B5, Potassium Folate, and
The nutritional values of the grapefruit varies with the colour (white, pink, or red).
Grapefruit is an excellent source of Vitamin C which plays a role in the following:
Supporting the immune system.
Reduce severity of cold symptoms. reduce severity of inflammatory conditions. is beneficial to promoting cardiovascular health.
Pink and Red Grapefruit appears to have anti-tumour activity and have a higher amount of vitamin A.
Interactions Of Grapefruit With Medications.
Interaction It is a situation in which a
substance affects the activity of the used medication by one of the following
The effect is increased. The effect is decreased. It produces a new effect.
Grapefruit Interacts when we take a
medicine orally (by mouth), it has to get into our blood stream to do its
During this a significant portion of the medicine is metabolized (changed) to inactive ingredients by a certain enzyme
in either the intestine (first-pass metabolism) or the liver, decreasing the amount of medication reaching the Blood.
Grapefruit juice interferes with the enzyme system responsible for the metabolism of many medications.
Therefore, the amount of medication available in the body will increase, possibly causing toxic effects.
Grapefruit juice can inhibit intestinal enzyme concentration for 24 to 72 hours.
Separating the times of medication
administration and grapefruit consumption is not a reasonable solution.
It is important to note that because of genetic differences, the extent of interaction differs from one patient to another.
Grapefruit and Statins:
Statins are medications that lower
cholesterol levels by blocking the enzyme responsible for cholesterol synthesis
in the body.
Satins are the most widely prescribed cholesterol lowering medications, since they affect every aspect in the cholesterol panel in a favourable way. The components in grapefruit prevent the enzyme system in the body from breaking down the statin leading to its accumulation in the body.
Taking one tablet of lovastatin (Mevacor)
with a glass of grapefruit juice
is the same as taking 12 to 15 tablets
with a glass of water.
The problems associated with taking grapefruit with stains are:
This rare but potentially life-threatening Side effect, The most common symptoms are:
Severe muscle aching throughout the entire body, Muscle weakness, dark or cola-colored urine.
The higher the dose of statins, the higher the risk of Rhabdomyolysis.
So far, the only statins significantly affected by this interaction are:
Other statins do not seem to demonstrate the same, profound effect with grapefruit as seen with the other statins
These would include:
Pravastatin (Pravachol ®)
Fluvastatin (Lescol ®)
This may be due to the fact that these statins are not broken
down by the same enzymes.
Grapefruit And Antihistamines:
Antihistamines are medications used to
treat allergies. Interaction of grapefruit with antihistamines like terfenadine
or astemizole leads to fatal cardiac arrhythmias (Irregular heart beat).
There are other non-sedating antihistamines which do not
interact with grapefruit juice. (e.g., loratidine (Claritin ®)
cetirizine (Zyrtec ®).
Grapefruit and Calcium Channel Blockers:
Calcium Channel Blockers are medications
that prevent calcium from entering cells of the heart and blood vessel walls,
resulting in lowering blood pressure.
Grapefruit juice is likely to increase the levels of Calcium
Channel Blockers in the blood causing the following:
Low blood pressure, Increased heart rate, dizziness, flushing, headache.
Grapefruit interacts with a wide range of
medications such as:
Psychiatric Medications, immune suppressants, pain medications (Methadone), impotence drugs, intestinal medications (Cisapride).
Grapefruit juice inhibits the body's ability to absorb some drugs like:
Losartan (for lowering blood pressure)
Digoxin (for treating congestive heart failure)
It has been shown that both grapefruit sections and grapefruit extract has the same effect on medications as grapefruit juice.
There are citrus fruits which can cause the
same drug interaction as grapefruit such as:
Seville orange (found in marmalade and jams), pomelos, tangelos.
Pomelo is also called the "Chinese grapefruit", it's native to southeast Asia. It is, in fact, an ancestor of the grapefruit.
The grapefruit was formed from crossing between the pomelo and the orange to give us the modern grapefruit varieties we know today. The tangelo is a hybrid between the pomelo and the tangerine. The fruit is known in some countries as "sweetie”.
A number of medications are reported to have interactions with grapefruit. Before taking any medication with grapefruit you have to make sure that there is no interaction. There are several other fruit juices available as a substitute to grapefruit juice. Always ask your doctor if unsure about anything regarding prescribed medication or treatment. you may want to print this page to show your doctor or medical advisor, or refer them to it.
The pineapple is a member of the bromeliad
family. It is extremely rare that bromeliads produce edible fruit. The
pineapple is the only available edible bromeliad today. Bromelain, a proteolytic enzyme, is the key to pineapple's
value. Proteolytic means "breaks down protein", which is why pineapple is known to be a digestive aid. It helps the
body digest proteins more efficiently. Bromelain is also considered an effective anti-inflammatory.
In Germany, bromelain is approved as a post-injury medication because it is thought to reduce inflammation and
Fresh pineapple is is high in Vitamin C but because of the Bromelain, it has the ability to reduce mucous in the throat.
If you have a cold with a productive cough, pineapple is commonly used in Europe as a post-operative measure to cut
mucous after certain sinus and throat operations.
Pineapple is valuable for easing indigestion, arthritis or sinusitis. The juice has an anathematic effect; it helps get rid of
intestinal worms. Regular ingestion of at least one half cup of fresh pineapple daily is purported to relieve painful joints
common to osteoarthritis. It also produces mild pain relief. Pineapple is also known to discourage blood clot
development. This makes it a valuable dietary addition for frequent fliers and others who may be at risk for blood
clots. Those individuals who eat fresh pineapple daily report fewer sinus problems related to allergies. In and of itself,
pineapple has a very low risk for allergies. Pineapple is high in manganese, a mineral that is critical to development of
strong bones and connective tissue. A cup of fresh pineapple will give you nearly 75% of the recommended daily
amount. It is particularly helpful to older adults, whose bones tend to become brittle with age. It's also good for a
healthier mouth, as the fresh juice discourages plaque growth.
It is a multiple fruit. One pineapple is actually made up of dozens of individual flowerets that grow together to form the
entire fruit. Each scale on a pineapple is evidence of a separate flower. The more scales on the pineapple, the
sweeter and juicier the taste. Pineapples stop ripening the minute they are picked. No special way of storing them will
help ripen them further. Colour is relatively unimportant in determining ripeness. Choose your pineapple by smell. If it
smells fresh, tropical and sweet, it will be a good fruit. We find it enjoyable because of its lush, sweet and exotic flavour,
but it may also be one of the most healthful foods available today. After you cut off the top, you can plant it. It should
grow much like a sweet potato will.
True facts about bananas (click to view)
Compare your tinned food and save money!
I noted something interesting at ASDA which will apply to other stores as well. 213gm Tins of RED salmon regardless of brand ASDA own brand, princess, john west. Although own brand labelled and priced differently ALL have the same factory numbering codes printed on the top of the can proving that they all have exactly the same content from the same Alaska canning plant. So buying the stores own brand will save a considerable sum of money without loss of quality! I wonder how many other goods in superstores are labelled in this way. I have checked Tesco own label same tins there appears to be couple of grams weight difference between identical sealed tins I checked, but Tesco one was slightly heavier although marked 212gm.. Sainsbury own brand tin not same so cant be compared. A friend who has worked work at Sainsbury’s for a long time told me this is common with a lot of products, so check items factory markings of all tinned food you buy at big grocery store chains against own brands you could save a fortune without loosing quality! One other related point for savers these tins have a life of 3 years +( check date when buying), If you can buy now at a good price ( 50p or more off or even not) what do you think it will cost to buy the SAME product in 2 years time? better investment than putting money in a long term savings account I would give a conservative estimate of at least 30 to 50% bit better than bank interest tax free AND you can eat the stuff if there are strikes or shortages! just store in dry place, unlike money under the bed (grin) it wont burn in event of fire (just cook..) And things would have to get very bad, and difficult for people to break in and steal it!....
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